A second hit for TMA

Blood. 2012 Aug 9;120(6):1152-4. doi: 10.1182/blood-2012-06-433235.


In this issue of Blood, Fuchs and colleagues provide evidence that circulating DNA and histones, presumably released from neutrophils, would be the second hit for development of thrombotic microangiopathies (TMAs), a group of life-threatening disorders characterized by thrombi in the microvasculature resulting in thrombocytopenia, microangiopathic hemolysis, and organ dysfunction.

Publication types

  • Comment

MeSH terms

  • DNA / blood*
  • Female
  • Humans
  • Male
  • Peroxidase / blood*
  • Thrombotic Microangiopathies / blood*
  • Thrombotic Microangiopathies / diagnosis*


  • DNA
  • Peroxidase