Ultra high-performance liquid chromatography with high-resolution mass spectrometry analysis of African mango (Irvingia gabonensis) seeds, extract, and related dietary supplements

J Agric Food Chem. 2012 Sep 5;60(35):8703-9. doi: 10.1021/jf302703u. Epub 2012 Aug 23.


Dietary supplements based on an extract from Irvingia gabonensis (African mango, AM) seeds are one of the popular herbal weight loss dietary supplements in the U.S. market. The extract is believed to be a natural and healthy way to lose weight and improve overall health. However, the chemical composition of AM-based dietary supplements (AMDSs) has never been reported. In this study, the chemical constituents of AM seeds, AM seeds extract (AMSE), and different kinds of commercially available AMDSs have been investigated using an ultra high-performance liquid chromatography with high resolution mass spectrometry method. Ellagic acid, mono-, di-, and tri-O-methyl-ellagic acids, and their glycosides were found as major components in AM seeds. These compounds may be used for quality control of AM extract and related dietary supplements.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Africa
  • Cellulose / chemistry*
  • Chromatography, High Pressure Liquid / methods*
  • Dietary Supplements / analysis*
  • Ellagic Acid / analysis
  • Flavonoids / analysis
  • Hydrolyzable Tannins / analysis
  • Mass Spectrometry / methods*
  • Placental Lactogen
  • Plant Extracts / chemistry*
  • Quality Control
  • Seeds / chemistry*
  • Weight Loss


  • Flavonoids
  • Hydrolyzable Tannins
  • Plant Extracts
  • dikanut
  • Ellagic Acid
  • Cellulose
  • Placental Lactogen