Hydroxyurea induced dermatomyositis-like eruption

Australas J Dermatol. 2012 Aug;53(3):e58-60. doi: 10.1111/j.1440-0960.2011.00774.x. Epub 2011 May 31.


Medication-induced dermatomyositis (DM) is rare, but a recent review highlighted hydroxyurea (HU) as the most common inciting agent. To aid diagnosis, HU-induced DM-like eruption (HU DM-LE) forms a distinct dermopathy where the typical cutaneous features of DM are without systemic involvement and co-exist with other HU-induced cutaneous findings such as severe xerosis, atrophy, stomatitis, cutaneous and mucosal ulceration and melanonychia. On cessation of HU the DM-LE clears avoiding unnecessary immunosuppression and demonstrating the importance of consideration of medication aetiology in DM presentations. We present a case report and review of the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Anemia, Megaloblastic / chemically induced
  • Antineoplastic Agents / adverse effects*
  • Dermatomyositis / chemically induced*
  • Dermatomyositis / pathology
  • Drug Eruptions / etiology*
  • Drug Eruptions / pathology
  • Female
  • Humans
  • Hydroxyurea / adverse effects*
  • Primary Myelofibrosis / drug therapy


  • Antineoplastic Agents
  • Hydroxyurea