A life-threatening flecainide overdose treated with intravenous fat emulsion

Pacing Clin Electrophysiol. 2013 Mar;36(3):e87-9. doi: 10.1111/j.1540-8159.2012.03485.x. Epub 2012 Aug 8.


Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life-threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life-threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life-threatening toxicity following flecainide overdose.

Publication types

  • Case Reports

MeSH terms

  • Anti-Arrhythmia Agents / poisoning*
  • Drug Overdose / therapy*
  • Emergency Treatment
  • Fat Emulsions, Intravenous / therapeutic use*
  • Flecainide / poisoning*
  • Humans
  • Male
  • Middle Aged


  • Anti-Arrhythmia Agents
  • Fat Emulsions, Intravenous
  • Flecainide