New insights on molecular mechanisms of renal aging

Am J Transplant. 2012 Nov;12(11):2892-900. doi: 10.1111/j.1600-6143.2012.04214.x. Epub 2012 Aug 6.

Abstract

Long-term transplant outcome is importantly influenced by the age of the organ donor. The mechanisms how age carries out its pathophysiological impact on graft survival are still not understood. One major contributing factor for the observed poor performance of old donor kidneys seems in particular the age-related loss in renal regenerative capacity. In this review, we will summarize recent findings about the molecular basis of renal aging with specific focus on the potential role of somatic cellular senescence and mitochondrial aging in renal transplant outcome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / genetics*
  • Animals
  • Cellular Senescence / genetics*
  • Cellular Senescence / physiology
  • Female
  • Genetic Markers / physiology
  • Graft Survival / genetics*
  • Graft Survival / physiology
  • Humans
  • Kidney Transplantation / adverse effects*
  • Kidney Transplantation / methods
  • Living Donors
  • Male
  • Mitochondria / genetics
  • Molecular Biology / methods
  • Sensitivity and Specificity
  • Tissue Donors

Substances

  • Genetic Markers