Rates and determinants of progressive aortic valve dysfunction in aortic coarctation

Int J Cardiol. 2013 Sep 10;167(6):2841-5. doi: 10.1016/j.ijcard.2012.07.028. Epub 2012 Aug 9.


Purpose: Aortic valve dysfunction is common in coarctation patients(CoA). Bicuspid aortic valve (BAV) in CoA is associated with aortic valve stenosis (AS), aortic valve regurgitation (AR), and ascending aortic dilatation. The aim of this study was to evaluate the progression of and predictors for aortic valve dysfunction in CoA.

Methods: 96 CoA patients prospectively underwent echocardiography twice between 2001 and 2010. AS was defined as an aortic valve gradient ≥ 20 mmHg, AR as none/minor, or moderate/severe. Aortic dilatation as an ascending aortic diameter ≥ 37 mm.

Results: All patients (median age 28.0 years, range 17-61 years; male 57%) were followed with a median follow-up of 7.0 years. Sixty patients (63%) had BAV. At baseline 10 patients had AS (10%, 9 BAV), 6 patients AR (6%, 3 BAV) and 11 patients aortic dilatation (11%, 11 BAV). At follow-up 15 patients had AS (15%, 13 BAV) and 12 patients AR. (13%, 8 BAV). Median AS progression was 1.1 mmHg/5 years (range - 13-28). Determinants for AS at follow-up were age (ß=0.20, P=0.01), aortic dilatation (ß=4.6, P=0.03), and baseline aortic valve gradient (ß=0.93, P<0.001). BAV was predictive for AR. (ß=0.91, P=0.049).

Conclusion: Progression of AS in adult CoA patients is mild in this young population. Older age, aortic dilatation and the baseline aortic valve gradient are determinants for AS at follow-up. BAV is predictive for AR. These findings point towards a common embryological pathway of both valvular and aortic disease in CoA.

Keywords: Aortic coarctation; Aortic dilatation; Aortic valve regurgitation; Aortic valve stenosis; Bicuspid aortic valve.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aortic Coarctation / diagnosis*
  • Aortic Coarctation / epidemiology*
  • Aortic Valve
  • Bicuspid Aortic Valve Disease
  • Databases, Factual / trends
  • Disease Progression*
  • Female
  • Follow-Up Studies
  • Heart Defects, Congenital / diagnosis*
  • Heart Defects, Congenital / epidemiology*
  • Heart Valve Diseases / diagnosis*
  • Heart Valve Diseases / epidemiology*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Registries
  • Young Adult