Acute lung injury and the acute respiratory distress syndrome in the injured patient

Scand J Trauma Resusc Emerg Med. 2012 Aug 10:20:54. doi: 10.1186/1757-7241-20-54.


Acute lung injury and acute respiratory distress syndrome are clinical entities of multi-factorial origin frequently seen in traumatically injured patients requiring intensive care. We performed an unsystematic search using PubMed and the Cochrane Database of Systematic Reviews up to January 2012. The purpose of this article is to review recent evidence for the pathophysiology and the management of acute lung injury/acute respiratory distress syndrome in the critically injured patient. Lung protective ventilation remains the most beneficial therapy. Future trials should compare intervention groups to controls receiving lung protective ventilation, and focus on relevant outcome measures such as duration of mechanical ventilation, length of intensive care unit stay, and mortality.

Publication types

  • Review

MeSH terms

  • Acute Lung Injury / etiology*
  • Acute Lung Injury / physiopathology
  • Acute Lung Injury / therapy
  • Age Factors
  • Aged
  • Black or African American
  • Brain Injuries / complications
  • Female
  • Flail Chest / complications
  • Flail Chest / etiology
  • Flail Chest / therapy
  • Humans
  • Male
  • Respiration, Artificial / adverse effects
  • Respiration, Artificial / methods*
  • Respiratory Distress Syndrome / etiology*
  • Respiratory Distress Syndrome / physiopathology
  • Respiratory Distress Syndrome / therapy
  • Risk Factors
  • Sex Factors
  • Transfusion Reaction
  • Trauma Severity Indices
  • Wounds and Injuries / complications*
  • Wounds, Nonpenetrating / complications