Fatal manganese intoxication due to an error in the elaboration of Epsom salts for a liver cleansing diet

Forensic Sci Int. 2012 Nov 30;223(1-3):e1-4. doi: 10.1016/j.forsciint.2012.07.010. Epub 2012 Aug 10.


We describe the case of a 50-year-old man with a fatal intoxication after accidental massive oral ingestion of manganese. The patient presented with lethargy, diffuse abdominal pain, vomiting, and profuse diarrhea after ingesting Epsom salts (magnesium sulfate heptahydrate) during a liver cleansing diet. Despite intensive care management with intubation, prone position ventilation, continuous venovenous hemofiltration, and multiple transfusions, he progressed to refractory shock with multiple organ dysfunction resulting in death within 72 h. Similar patients arrived at several hospitals with identical epidemiology (all had ingested the same salt obtained in the same place). Clinical and forensic investigations (X-ray diffraction) discovered that the supplier had mistakenly prepared the salts with hydrated manganese sulfate instead of magnesium sulfate heptahydrate. The results enabled the other patients to be successfully treated for hydrated manganese sulfate intoxication with life support in the intensive care unit and chelation therapy (EDTA). We describe the clinical presentation of acute manganese poisoning and alert professionals to the risk of an increasingly popular diet. This case demonstrates the importance of collaboration between clinicians, pathologists, and forensic scientists to resolve a difficult-to-diagnose case.

Publication types

  • Case Reports

MeSH terms

  • Accidents
  • Administration, Oral
  • Forensic Pathology
  • Forensic Toxicology
  • Hemorrhage / pathology
  • Humans
  • Liver / pathology
  • Male
  • Manganese Compounds / analysis
  • Manganese Compounds / pharmacokinetics
  • Middle Aged
  • Multiple Organ Failure / chemically induced
  • Necrosis
  • Pancreas / pathology
  • Shock / chemically induced
  • Spectrophotometry, Atomic
  • Sulfates / analysis
  • Sulfates / pharmacokinetics
  • Sulfates / poisoning*
  • Tissue Distribution
  • X-Ray Diffraction


  • Manganese Compounds
  • Sulfates
  • manganese sulfate