How the ubiquitin proteasome system regulates the regulators of transcription

Transcription. 2012 Sep-Oct;3(5):235-9. doi: 10.4161/trns.21249. Epub 2012 Sep 1.


The ubiquitin proteasome system plays an important role in transcription. Monoubiquitination of activators is believed to aid their function, while the 26S proteasomal degradation of repressors is believed to restrict their function. What remains controversial is the question of whether the degradation of activators aids or restricts their function.

Keywords: Gal4; conditional protein degradation; transcription; ubiquitin.

MeSH terms

  • Proteasome Endopeptidase Complex / metabolism*
  • Transcription Factors / metabolism*
  • Transcription, Genetic
  • Ubiquitin / metabolism*
  • Ubiquitination


  • Transcription Factors
  • Ubiquitin
  • Proteasome Endopeptidase Complex