The Kulinkovich hydroxycyclopropanation reaction in natural product synthesis

Org Biomol Chem. 2012 Oct 14;10(38):7649-65. doi: 10.1039/c2ob26082d.


The Kulinkovich cyclopropanation reaction provides a flexible and convenient method for the synthesis of cyclopropanols. Together with the diverse chemistry of the cyclopropanol unit, it offers access to a wide range of functionalised unsaturated and saturated compounds. The successful use in the synthesis of natural compounds is outlined in this perspective.

MeSH terms

  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Carboxylic Acids / chemistry
  • Cyclization
  • Cyclopropanes / chemistry*
  • Esters / chemistry
  • Ethers, Cyclic / chemical synthesis*
  • Ethers, Cyclic / chemistry
  • Molecular Structure


  • Biological Products
  • Carboxylic Acids
  • Cyclopropanes
  • Esters
  • Ethers, Cyclic
  • cyclopropanol