Regulation of the epidermal growth factor receptor by growth-modulating agents

Biotechnol Appl Biochem. 1990 Oct;12(5):473-7.


The epidermal growth factor (EGF) receptor, a tyrosine kinase which mediates the mitogenic and tumorigenic action of EGF on epithelial cells and fibroblasts, is a target for the regulatory action of other growth-modulating agents. We have identified at least three mechanisms by which heterologous agents such as tumor promoters regulate the EGF receptor: modulation of receptor binding or kinase activity through phosphorylation, down regulation of the receptor through internalization, and enhanced receptor synthesis through transcriptional activation. Both calcium- and sodium-dependent signaling pathways play a role in one or more of these processes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carcinogens / pharmacology*
  • ErbB Receptors / drug effects*
  • Growth Substances / pharmacology*
  • Toxins, Biological / pharmacology*


  • Carcinogens
  • Growth Substances
  • Toxins, Biological
  • ErbB Receptors