Lack of effect of co-trimoxazole on the pharmacokinetics and pharmacodynamics of nifedipine

Br J Clin Pharmacol. 1990 Dec;30(6):889-91. doi: 10.1111/j.1365-2125.1990.tb05456.x.

Abstract

The pharmacokinetics of nifedipine and its primary oxidised metabolite, M-I were studied in nine healthy volunteers following a single oral dose of 20 mg nifedipine alone or after pretreatment with oral co-trimoxazole. Following pretreatment with co-trimoxazole, no significant effect was detected on maximum plasma concentration, elimination half-life, or area under the plasma concentration-time curve of either nifedipine or M-I, nor on the blood pressure response to nifedipine.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Drug Interactions
  • Half-Life
  • Humans
  • Male
  • Nifedipine / blood
  • Nifedipine / pharmacokinetics*
  • Premedication
  • Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology*

Substances

  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Nifedipine