Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2012, 194829

Bisphenol A Induces Hepatotoxicity Through Oxidative Stress in Rat Model


Bisphenol A Induces Hepatotoxicity Through Oxidative Stress in Rat Model

Zeinab K Hassan et al. Oxid Med Cell Longev.


Reactive oxygen species (ROS) are cytotoxic agents that lead to significant oxidative damage. Bisphenol A (BPA) is a contaminant with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells. Due to limited information concerning the effect of BPA on liver, this study investigates whether BPA causes hepatotoxicity by induction of oxidative stress in liver. Rats were divided into five groups: The first four groups, BPA (0.1, 1, 10, 50 mg/kg/day) were administrated orally to rats for four weeks. The fifth group was taken water with vehicle. The final body weights in the 0.1 mg group showed a significant decrease compared to control group. Significant decreased levels of reduced glutathione, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and catalase activity were found in the 50 mg BPA group compared to control groups. High dose of BPA (50 mg/kg) significantly increased the biochemical levels of ALT, ALP and total bilirubin. BPA effect on the activity of antioxidant genes was confirmed by real time PCR in which the expression levels of these genes in liver tissue were significantly decrease compared to control. Data from this study demonstrate that BPA generate ROS and reduce the antioxidant gene expression that causes hepatotoxicity.

Similar articles

See all similar articles

Cited by 49 PubMed Central articles

See all "Cited by" articles


    1. Humblet O, Birnbaum L, Rimm E, Mittleman MA, Hauser R. Dioxins and cardiovascular disease mortality. Environmental Health Perspectives. 2008;116(11):1443–1448. - PMC - PubMed
    1. Elobeid MA, Allison DB. Putative environmental-endocrine disruptors and obesity: a review. Current Opinion in Endocrinology, Diabetes and Obesity. 2008;15(5):403–408. - PMC - PubMed
    1. Willhite CC, Ball GL, McLellan CJ. Derivation of a bisphenol a oral reference dose (RfD) and drinking-water equivalent concentration. Journal of Toxicology and Environmental Health B. 2008;11(2):69–146. - PubMed
    1. Crain DA, Eriksen M, Iguchi T, et al. An ecological assessment of bisphenol-A: evidence from comparative biology. Reproductive Toxicology. 2007;24(2):225–239. - PubMed
    1. Korkmaz A, Ahbab MA, Kolankaya D, Barlas N. Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats. Food and Chemical Toxicology. 2010;48(10):2865–2871. - PubMed

Publication types

MeSH terms