[Therapeutic siRNAs and non-viral systems for their delivery]

Mol Biol (Mosk). May-Jun 2012;46(3):371-86.
[Article in Russian]

Abstract

Gene-directed therapy with small interfer-ring RNA (siRNA) has a tremedous potential and in the future will undoubtly occupy one of the leading positions among other therapeutic methods. The lack of efficient and targeted delivery vectors delays the successful implementation of this method in clinic. To develop such systems, one needs a comprehansive insight into the processes of interactions between siRNAs, its delivery systems and an organism. This review covers properties of therapeutic siRNAs and non-viral systems for their delivery.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Aptamers, Nucleotide / chemistry
  • Drug Delivery Systems / methods*
  • Genetic Therapy*
  • Hemorheology
  • Humans
  • Liposomes / chemistry
  • Nanoparticles / chemistry
  • Particle Size
  • RNA Interference*
  • RNA, Small Interfering / chemistry*
  • RNA, Small Interfering / genetics
  • Static Electricity

Substances

  • Aptamers, Nucleotide
  • Liposomes
  • RNA, Small Interfering