[Types of non-viral delivery systems of small interfering RNA]

Mol Biol (Mosk). May-Jun 2012;46(3):387-401.
[Article in Russian]

Abstract

To date, RNA interference remains the most powerful and promising tool for gene-targeted therapy. Several problems still have to be solved for its successful use in clinics. One of the main issues is the siRNA's efficient delivery. This review covers various types of nonviral siRNA delivery systems.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Aptamers, Nucleotide / chemistry
  • Biocompatible Materials / chemistry
  • Drug Delivery Systems / methods*
  • Genetic Therapy*
  • Humans
  • Lipids / chemistry
  • Lipopeptides / chemistry
  • Liposomes / chemistry
  • Nanoparticles / chemistry
  • Polymers / chemistry
  • RNA Interference*
  • RNA, Small Interfering / chemistry*
  • RNA, Small Interfering / genetics
  • Static Electricity

Substances

  • Aptamers, Nucleotide
  • Biocompatible Materials
  • Lipids
  • Lipopeptides
  • Liposomes
  • Polymers
  • RNA, Small Interfering