Abstract
The conserved multi-subunit Elongator complex was initially described as a RNA polymerase II (RNAPII) associated transcription elongation factor, but since has been shown to be involved a variety of different cellular activities. Here, we summarize recent developments in the field and discuss the resulting implications for the proposed multi-functionality of Elongator.
Keywords:
Elongator; tRNA modification; transcription elongation.
MeSH terms
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Animals
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Histone Acetyltransferases / chemistry
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Histone Acetyltransferases / genetics*
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Humans
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Intracellular Signaling Peptides and Proteins / chemistry
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Intracellular Signaling Peptides and Proteins / genetics
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / genetics
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Protein Biosynthesis
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Transcription, Genetic
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Transcriptional Elongation Factors / chemistry
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Transcriptional Elongation Factors / genetics*
Substances
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Intracellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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Transcriptional Elongation Factors
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Histone Acetyltransferases