A review of dietary and non-dietary exposure to bisphenol-A

Food Chem Toxicol. 2012 Oct;50(10):3725-40. doi: 10.1016/j.fct.2012.07.059. Epub 2012 Aug 4.


Due to the large number of applications of bisphenol-A (BPA), the human exposure routes are multiple. We aimed to review shortly the food and non-food sources of BPA, and to evaluate their contribution to the human exposure. Food sources discussed here include epoxy resins, polycarbonate and other applications, such as paperboard and polyvinylchloride materials. Among the non-food sources, exposures through dust, thermal paper, dental materials, and medical devices were summarized. Based on the available data for these exposure sources, it was concluded that the exposure to BPA from non-food sources is generally lower than that from exposure from food by at least one order of magnitude for most studied subgroups. The use of urinary concentrations from biomonitoring studies was evaluated and the back-calculation of BPA intake seems reliable for the overall exposure assessment. In general, the total exposure to BPA is several orders of magnitude lower than the current tolerable daily intake of 50 μg/kg bw/day. Finally, the paper concludes with some critical remarks and recommendations on future human exposure studies to BPA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Benzhydryl Compounds / chemistry*
  • Benzhydryl Compounds / toxicity*
  • Environmental Exposure*
  • Environmental Pollutants / chemistry
  • Environmental Pollutants / toxicity
  • Food Contamination*
  • Humans
  • Phenols / chemistry*
  • Phenols / toxicity*


  • Benzhydryl Compounds
  • Environmental Pollutants
  • Phenols
  • bisphenol A