Pd-catalyzed double C-H bond activation of diaryl ketones for the synthesis of fluorenones

Chem Commun (Camb). 2012 Sep 28;48(75):9379-81. doi: 10.1039/c2cc34344d. Epub 2012 Aug 14.

Abstract

An efficient synthesis of fluorenones from diaryl ketones by Pd-catalyzed oxidative cyclization is described. A possible mechanism involving a carbonyl group assisted ortho-C-H activation and cyclometalation followed by a second C-H activation to form a six-membered palladacycle and reductive elimination is proposed.