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. 2012 Oct;78(15):1636-8.
doi: 10.1055/s-0032-1315208. Epub 2012 Aug 13.

Inhibition of Herpes Simplex Virus Type 1 by Thymol-Related Monoterpenoids

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Inhibition of Herpes Simplex Virus Type 1 by Thymol-Related Monoterpenoids

Wen-Lin Lai et al. Planta Med. .

Abstract

This study examined the anti-herpes simplex virus type I activity of the major constituents of several essential oils. Plaque reduction assays were performed to evaluate anti-herpes simplex virus type I activity. Thymol and carvacrol both possessed significant antiviral activity with an IC₅₀ of 7 µM, and herpes simplex virus type I was 90 % inactivated within 1 hr. The mode of antiviral action was shown to affect the virion directly. Evidence was also observed by electron microscopy. Evaluation of the structural requirements for antiviral activity of thymol-related monoterpenoids revealed that aliphatic side chains had a minor effect, while a hydrophilic group on the benzene ring was sufficient for activity. Our results suggest that thymol and carvacrol are potential candidates for topical therapeutic application to reduce herpes simplex virus transmission.

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