[Essential hypertension, a complex trait]

Rev Med Liege. 2012 May-Jun;67(5-6):279-85.
[Article in French]

Abstract

Essential hypertension, defined as a blood pressure equal to or above 140/90 mmHg, is a common (25% of the population), but complex disease the phenotype of which results from interactions between numerous genes and environmental factors. The role attributable to genetic factors amounts to some 25% among hypertensive families, but can reach 65% when monozygotic twins are compared. In the present state of our knowledge, there is no hope to obtain a genetic test of value for the diagnosis and prognosis of hypertension. An individualized environmental approach, applied early in life, is the only worhtwhile attitude. Nonetheless, in the presence of a subject with still normal blood pressure values, but with a family history of hypertension, the physician should firmly recommend an appropriate hygieno-dietetic lifestyle with a view to lower blood pressure, or retard the development of arterial hypertension

Publication types

  • Review

MeSH terms

  • Animals
  • Body Weight / physiology
  • Causality
  • Environment
  • Feeding Behavior / physiology
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Humans
  • Hypertension / epidemiology
  • Hypertension / etiology*
  • Hypertension / genetics
  • Models, Biological
  • Motor Activity / physiology