Hypomagnesemia associated with a proton pump inhibitor

Intern Med. 2012;51(16):2231-4. doi: 10.2169/internalmedicine.51.7748. Epub 2012 Aug 15.


Severe hypomagnesemia is a serious clinical condition. Proton pump inhibitor (PPI) induced hypomagnesemia has been recognized since 2006. In March 2011 the U.S. Food and Drug Administration advised that long-term use of PPI can induce hypomagnesemia. We report the first Japanese case of hypomagnesemia associated with chronic use of PPIs in a 64-year-old man hospitalized for nausea, bilateral ankle arthritis, and tremor of the extremities who had convulsions 3 days after admission. Blood analysis showed severe hypomagnesemia. He had been taking rabeprazole (10 mg/day) for 5 years. After stopping rabeprazole and correcting the electrolytes imbalances, his symptoms improved without recurrence.

Publication types

  • Case Reports

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles / adverse effects*
  • 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use
  • Gastroesophageal Reflux / chemically induced
  • Humans
  • Magnesium / blood*
  • Magnesium Deficiency / chemically induced
  • Male
  • Middle Aged
  • Proton Pump Inhibitors / adverse effects*
  • Proton Pump Inhibitors / therapeutic use
  • Rabeprazole


  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Proton Pump Inhibitors
  • Rabeprazole
  • Magnesium