Role changes of β-catenin in kidney injury and repair

Kidney Int. 2012 Sep;82(5):509-11. doi: 10.1038/ki.2012.155.


Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of β-catenin in acute kidney injury. Although β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, β-catenin suppresses wound healing. Moreover, continuous activation of β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by β-catenin and related signaling in kidney injury, repair, and fibrosis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Class I Phosphatidylinositol 3-Kinases / metabolism*
  • Doxorubicin*
  • Glomerulosclerosis, Focal Segmental / enzymology*
  • Kidney / enzymology*
  • Male
  • Proteinuria / enzymology*
  • Signal Transduction*
  • Smad3 Protein / metabolism*


  • Smad3 Protein
  • Smad3 protein, mouse
  • Doxorubicin
  • 1-phosphatidylinositol 3-kinase p110 subunit, mouse
  • Class I Phosphatidylinositol 3-Kinases