Cognitive function at 2443 μmol/l creatinine

BMC Nephrol. 2012 Aug 15;13:86. doi: 10.1186/1471-2369-13-86.


Background: One hallmark of uremia is the impairment of neuro-cognitive function. Anecdotal clinical description from the early days of chronic dialysis therapy impressively illustrates the improvement of those functions by chronic hemodialysis treatment. Fortunately, today, uremia is only rarely observed in industrialized countries as many patients seek medical/nephrological attention prior to the occurrence of deadly complications of uremia.

Case presentation: We report a rare case of severe uremia and describe the day to day improvement in neuro-cognitive function by dialysis using state of the arte test battery--starting at a serum creatinine of 2443 μmol/l.

Conclusions: Especially executive functions, which are assumed to be localized in the frontal cerebral regions, are impaired in severe uremia and improve remarkably with the correction of severe uremia, i.e., initiation of dialysis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Cognition Disorders / blood*
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / therapy
  • Creatinine / blood*
  • Humans
  • Male
  • Renal Dialysis / methods
  • Uremia / blood*
  • Uremia / diagnosis*
  • Uremia / therapy


  • Biomarkers
  • Creatinine