Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation

Am J Surg Pathol. 2012 Sep;36(9):1376-84. doi: 10.1097/PAS.0b013e318261089c.

Abstract

Secondary cancers developing after allogeneic hematopoietic stem cell transplantation generally originate from recipient-derived cells. In this study, we analyzed the tumor cell origin of 5 epithelial malignant tumors (esophageal squamous cell carcinoma, lung adenocarcinoma, gastric adenocarcinoma, pharyngeal squamous cell carcinoma, and thyroid papillary carcinoma) that developed after allogeneic peripheral blood stem cell transplantation using anti-AE1/3 immunofluorescence with fluorescence in situ hybridization analysis for sex chromosomes and/or short-tandem repeat microsatellite analysis of laser-microdissected tumor cells. The results revealed that 1 of these 5 cancers was derived from donor cells. In this case, transfused pluripotent cells, which include both mesenchymal stem cells and hematopoietic stem cells, might have given rise to epithelial malignant cells. Our observations suggest that transfused peripheral blood cells may be involved in the development of cancers after allogeneic peripheral blood stem cell transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / etiology*
  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Adenocarcinoma, Papillary / etiology*
  • Adenocarcinoma, Papillary / genetics
  • Adenocarcinoma, Papillary / pathology
  • Adult
  • Anion Exchange Protein 1, Erythrocyte / genetics
  • Antiporters / genetics
  • Bone Marrow Cells / chemistry
  • Bone Marrow Cells / pathology
  • Carcinoma, Squamous Cell / etiology*
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / pathology
  • Cell Lineage
  • DNA, Neoplasm / analysis
  • Esophageal Neoplasms / etiology
  • Esophageal Neoplasms / genetics
  • Esophageal Neoplasms / pathology
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • In Situ Hybridization, Fluorescence
  • Laser Capture Microdissection
  • Lung Neoplasms / etiology
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Male
  • Microsatellite Repeats / genetics
  • Middle Aged
  • Neoplasms, Multiple Primary / etiology*
  • Neoplasms, Multiple Primary / genetics
  • Neoplasms, Multiple Primary / pathology
  • Peripheral Blood Stem Cell Transplantation / adverse effects*
  • Pharyngeal Neoplasms / etiology
  • Pharyngeal Neoplasms / genetics
  • Pharyngeal Neoplasms / pathology
  • Sex Chromosomes / genetics
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / pathology
  • Thyroid Neoplasms / etiology
  • Thyroid Neoplasms / genetics
  • Thyroid Neoplasms / pathology
  • Tissue Donors*
  • Transplantation Chimera

Substances

  • Anion Exchange Protein 1, Erythrocyte
  • Antiporters
  • DNA, Neoplasm
  • SLC4A3 protein, human