Reduction of the severity of experimental gastric and duodenal ulceration by interleukin-1 beta

Eur J Pharmacol. 1990 Sep 21;186(2-3):279-84. doi: 10.1016/0014-2999(90)90444-b.


Interleukin-1 beta (IL-1 beta) has been reported to stimulate prostaglandin synthesis by the rat stomach in vitro and to inhibit gastric acid secretion in vivo. We have therefore tested the hypothesis that IL-1 beta might have protective actions in experimental models of gastroduodenal ulceration. IL-1 beta, given i.p., dose and time dependently reduced the severity of ethanol-induced gastric damage. A pretreatment time of 90 min was found to produce the greatest reduction of damage, while doses of 0.1 micrograms/kg or greater were found to produce significant effects. The protective actions of IL-1 beta were abolished by prior boiling or by pretreatment of the animals with indomethacin, and were not shared by the nonapeptide fragment 163-171. IL-1 beta also reduced the severity of gastric damage induced by indomethacin and the duodenal ulceration induced by cysteamine. The results indicate that IL-1 beta has protective actions in three separate experimental models of gastroduodenal ulceration. The mechanism of action of IL-1 beta is not entirely clear, but contributions of endogenous prostaglandin synthesis and inhibition of gastric acid secretion cannot be excluded.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cysteamine
  • Duodenal Ulcer / chemically induced
  • Duodenal Ulcer / prevention & control*
  • Ethanol
  • Indomethacin
  • Injections, Intraperitoneal
  • Interleukin-1 / administration & dosage
  • Interleukin-1 / pharmacology
  • Interleukin-1 / therapeutic use*
  • Interleukin-1beta
  • Male
  • Peptide Fragments / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Recombinant Proteins / therapeutic use
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / prevention & control*


  • Interleukin-1
  • Interleukin-1beta
  • Peptide Fragments
  • Recombinant Proteins
  • interleukin-1beta (163-171)
  • Ethanol
  • Cysteamine
  • Indomethacin