Measurement of quantifiable parameters by time-density curves in the elastase-induced aneurysm model: first results in the comparison of a flow diverter and a conventional aneurysm stent

Eur Radiol. 2013 Feb;23(2):521-7. doi: 10.1007/s00330-012-2611-2. Epub 2012 Aug 16.


Background: Quantifiable parameters to evaluate the effectiveness of flow diverters (FDs) are desirable. We measured time-density curves (TDCs) and calculated quantifiable parameters in the rabbit elastase-induced aneurysm model after stent (Neuroform [NF]) and FD (Pipeline embolisation device [PED]) treatment.

Methods: Sixteen rabbit elastase-induced aneurysms were treated with FD (n = 9) or NF (n = 5). Angiography was performed before and after treatment and TDCs were created. The time to peak (TTP), the full width at half maximum (FWHM) and the average slope of the curve which represent the inflow (IF) and outflow (OF) were calculated.

Results: Mean values before treatment were TTP = 0.8 s, FWHM = 1.2 s, IF = 153.5 and OF = -54.9. After PED treatment, the TTP of 1.8 s and FWHM of 47.8 s were extended. The IF was 31.2 and the OF was -11.5 and therefore delayed. The values after NF treatment (TTP = 1.1 s, FWHM = 1.8 s, IF = 152.9, OF = -33.2) changed only slightly.

Conclusion: It was feasible to create TDCs in the rabbit aneurysm model. Parameters describing the haemodynamic effect of PED and NF were calculated and were different according to the type of device used. These parameters could possibly serve as predictive markers for aneurysm occlusion.

Publication types

  • Comparative Study

MeSH terms

  • Aneurysm / diagnostic imaging*
  • Aneurysm / therapy*
  • Angiography, Digital Subtraction
  • Animals
  • Blood Flow Velocity
  • Blood Vessel Prosthesis*
  • Disease Models, Animal
  • Intracranial Aneurysm / diagnostic imaging
  • Intracranial Aneurysm / therapy*
  • Pancreatic Elastase / adverse effects
  • Pancreatic Elastase / pharmacology
  • Rabbits
  • Random Allocation
  • Sensitivity and Specificity
  • Stents*
  • Subclavian Artery
  • Time Factors
  • Vascular Patency / physiology


  • Pancreatic Elastase