Abstract
We describe the synthesis of a fluorescent deoxyguanosine derivative that co-assembles (in water) with an unlabeled analogue into a heteromeric supramolecular G-quadruplex, which forms a host-guest complex with doxorubicin as evidenced by FRET experiments.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents / chemistry*
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Deoxyguanosine / analogs & derivatives
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Deoxyguanosine / chemical synthesis
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Deoxyguanosine / chemistry
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Doxorubicin / chemistry*
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Fluorescence Resonance Energy Transfer
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry
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G-Quadruplexes*
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Macromolecular Substances / chemistry
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Models, Molecular
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Molecular Structure
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Temperature
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Water / chemistry
Substances
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Antineoplastic Agents
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Fluorescent Dyes
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Macromolecular Substances
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Water
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Doxorubicin
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Deoxyguanosine