Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway

Biomed Pharmacother. 2012 Oct;66(7):535-40. doi: 10.1016/j.biopha.2012.04.006. Epub 2012 May 20.

Abstract

MiRNAs play an important role in regulating tumor migration and invasion, and abnormal expression of miRNAs occurs in various kinds of human cancers. In this essay, it is reported that the level of miRNA-218 decreases in metastatic breast cancer cells, moreover, miRNA-218 suppresses breast cancer cells migration and invasion through binding Robo1 (one of Slit receptors) to its 3'UTR. MiRNA-218 restoration suppresses Robo1 expression and inhibits breast cancer cells invasion and migration. What the results describe is that the function of Robo1 regulated by miRNA-218 may provide a new strategy for inhibiting migration and invasion of breast cancer cells.

MeSH terms

  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Cell Line, Tumor
  • Cell Movement
  • Female
  • Gene Silencing
  • HeLa Cells
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • MicroRNAs / genetics*
  • Neoplasm Invasiveness
  • Nerve Tissue Proteins / metabolism*
  • Receptors, Immunologic / metabolism*

Substances

  • Intercellular Signaling Peptides and Proteins
  • MIRN218 microRNA, human
  • MicroRNAs
  • Nerve Tissue Proteins
  • Receptors, Immunologic
  • roundabout protein
  • Slit homolog 2 protein