Radioprotective property of polysaccharide in Tinospora cordifolia

Indian J Biochem Biophys. 2003 Feb;40(1):22-6.

Abstract

Radioprotective activity of a polysaccharide preparation from the Indian medicinal plant. Tinospora cordifolia Miers has been established using Saccharomyces cerevisiae X2180 strain as the in vivo test model. The entire activity could be attributed to the radical scavenging capacity of the preparation, as it did not enhance the expression of the protective enzymes, catalase and superoxide dismutase in the yeast cells.

MeSH terms

  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • DNA Damage
  • Galactans / chemistry
  • Oxidative Stress / drug effects
  • Oxidative Stress / radiation effects
  • Polysaccharides / chemistry
  • Polysaccharides / pharmacology*
  • Radiation-Protective Agents / chemistry
  • Radiation-Protective Agents / pharmacology*
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae / radiation effects
  • Tinospora / chemistry*

Substances

  • Galactans
  • Polysaccharides
  • Radiation-Protective Agents
  • arabinogalactan