Molecular and functional characterization of early human hematopoiesis

Ann N Y Acad Sci. 2012 Aug;1266:68-71. doi: 10.1111/j.1749-6632.2012.06577.x.


Through improvements in xenograft assay methods and in the identification of novel cell surface markers, significant progress has been made in our understanding of the human hematopoietic stem and progenitor hierarchy. The isolation of clonally pure populations of stem cells and early progenitors opens the way to carry out gene expression profiling studies to uncover the molecular regulators of each developmental step and to gain insight into the process of lineage commitment in human hematopoiesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Separation
  • Hematopoiesis / genetics*
  • Hematopoiesis / physiology*
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Lymphocyte Subsets / cytology
  • Lymphocyte Subsets / metabolism
  • Mice
  • Multipotent Stem Cells / cytology
  • Multipotent Stem Cells / metabolism
  • Transplantation, Heterologous