Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB

J Dermatol Sci. 2012 Oct;68(1):63-6. doi: 10.1016/j.jdermsci.2012.07.010. Epub 2012 Aug 9.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimicrobial Cationic Peptides / genetics
  • Antimicrobial Cationic Peptides / metabolism*
  • Cells, Cultured
  • Enzyme Activation
  • Humans
  • Interleukin-1 / metabolism*
  • Keratinocytes / drug effects
  • Keratinocytes / enzymology
  • Keratinocytes / immunology
  • Keratinocytes / metabolism*
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • Mitogen-Activated Protein Kinases / metabolism*
  • NF-kappa B / metabolism*
  • Phosphorylation
  • Protein Kinase Inhibitors / pharmacology
  • S100 Calcium Binding Protein A7
  • S100 Proteins / genetics
  • S100 Proteins / metabolism*
  • Signal Transduction
  • Time Factors
  • Up-Regulation

Substances

  • Antimicrobial Cationic Peptides
  • Interleukin-1
  • NF-kappa B
  • Protein Kinase Inhibitors
  • S100 Calcium Binding Protein A7
  • S100 Proteins
  • S100A7 protein, human
  • ropocamptide
  • Mitogen-Activated Protein Kinases