Poxvirus use a "gene accordion" to tune out host defenses

Cell. 2012 Aug 17;150(4):671-2. doi: 10.1016/j.cell.2012.07.026.

Abstract

A multistep process of gene amplification, mutation, and reduction allows poxvirus to overcome host antiviral defenses. The mechanism speeds genetic adaptation and promises to be broadly applicable in many biological settings.

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