Endothelial function and the regulation of muscle protein anabolism in older adults

Nutr Metab Cardiovasc Dis. 2013 Dec;23 Suppl 1(0 1):S44-50. doi: 10.1016/j.numecd.2012.03.013. Epub 2012 Aug 17.


Sarcopenia, the loss of skeletal muscle mass and function with aging, is a major contributor to frailty and morbidity in older adults. Recent evidence has emerged suggesting that endothelial dysfunction and insulin resistance of muscle protein metabolism may significantly contribute to the development of sarcopenia. In this article we review: 1) recent studies and theories on the regulation of skeletal muscle protein balance in older adults; 2) the link between insulin resistance of muscle protein synthesis and endothelial dysfunction in aging; 3) mechanisms for impaired endothelial responsiveness in aging; and 4) potential treatments that may restore the endothelial responsiveness and muscle protein anabolic sensitivity in older adults.

Keywords: Endothelial dysfunction; Insulin resistance; Muscle protein metabolism; Sarcopenia.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / metabolism
  • Aging / pathology
  • Endothelium / cytology
  • Endothelium / metabolism*
  • Humans
  • Metabolism / physiology*
  • Muscle Proteins / metabolism*
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / metabolism*
  • Sarcopenia / metabolism*
  • Sarcopenia / pathology


  • Muscle Proteins