Next-generation digital information storage in DNA

Science. 2012 Sep 28;337(6102):1628. doi: 10.1126/science.1226355. Epub 2012 Aug 16.


Digital information is accumulating at an astounding rate, straining our ability to store and archive it. DNA is among the most dense and stable information media known. The development of new technologies in both DNA synthesis and sequencing make DNA an increasingly feasible digital storage medium. We developed a strategy to encode arbitrary digital information in DNA, wrote a 5.27-megabit book using DNA microchips, and read the book by using next-generation DNA sequencing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Composition
  • Computer Storage Devices*
  • DNA* / biosynthesis
  • DNA* / chemistry
  • DNA* / genetics
  • Escherichia coli / genetics
  • Genetic Code*
  • Information Storage and Retrieval / methods*
  • Mycoplasma mycoides / genetics
  • Oligonucleotide Array Sequence Analysis
  • Sequence Analysis, DNA


  • DNA