Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women

J Clin Endocrinol Metab. 2012 Nov;97(11):4061-70. doi: 10.1210/jc.2012-2121. Epub 2012 Aug 17.


Context: Selenium status may have direct effects on bone and indirect effects through changes in thyroid hormone sensitivity.

Objective: We hypothesized that variation in selenium status in healthy euthyroid postmenopausal women is associated with differences in bone turnover, bone mineral density (BMD) and fracture susceptibility.

Design: The Osteoporosis and Ultrasound Study (OPUS) is a 6-yr prospective study of fracture-related factors.

Setting: The study was comprised of a population-based cohort from five European cities.

Participants: A total of 2374 postmenopausal women participated. Subjects with thyroid disease and nonthyroidal illness and those receiving drugs affecting thyroid status or bone metabolism were excluded, leaving a study population of 1144.

Interventions: There were no interventions.

Main outcome measures: We measured selenium (micrograms per liter); selenoprotein P (milligrams per liter); free T(4) (picomoles per liter); free T(3) (picomoles per liter); TSH (milliunits per liter); bone turnover markers; BMD; and vertebral, hip, and nonvertebral fractures.

Results: Higher selenium levels were associated with higher hip BMD at study entry (β = 0.072, P = 0.004) and lower levels of bone formation (osteocalcin: β = -0.101, P < 0.001; procollagen type 1 N-terminal propeptide: β = -0.074, P = 0.013) and resorption markers (C-telopeptide of type 1 collagen: β = -0.058, P = 0.050; N-telopeptide of type 1 collagen: β = -0.095, P = 0.002). Higher selenoprotein P was associated with higher hip (β = 0.113, P < 0.001) and lumbar spine BMD (β = 0.088, P = 0.003) at study entry, higher hip BMD after the 6-yr follow-up (β = 0.106, P = 0.001) and lower osteocalcin (β = -0.077, P = 0.009), C-telopeptide of type 1 collagen (β = -0.075, P = 0.012), and N-telopeptide of type 1 collagen (β = -0.110, P < 0.001).

Conclusion: Selenium status is inversely related to bone turnover and positively correlated with BMD in healthy euthyroid postmenopausal women independent of thyroid status.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bone Density / physiology*
  • Female
  • Fractures, Bone / blood
  • Fractures, Bone / physiopathology*
  • Humans
  • Middle Aged
  • Postmenopause / blood
  • Postmenopause / physiology*
  • Prospective Studies
  • Selenium / blood*
  • Selenoprotein P / blood
  • Thyroid Hormones / blood
  • Women's Health


  • Selenoprotein P
  • Thyroid Hormones
  • Selenium