Parallel microflow photochemistry: process optimization, scale-up, and library synthesis

Org Lett. 2012 Sep 7;14(17):4342-5. doi: 10.1021/ol301773r. Epub 2012 Aug 20.


A novel, multimicrocapillary flow reactor (MμCFR) was constructed and applied to a series of sensitized photoadditions involving 2(5H)-furanones. The reactor allowed for rapid and energy-, time-, and space-efficient sensitizer screening, process optimization, validation, scale-up, and library synthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Combinatorial Chemistry Techniques
  • Furans / chemical synthesis*
  • Furans / chemistry*
  • Molecular Structure
  • Photochemical Processes


  • Furans