Planar cell polarity and the developmental control of cell behavior in vertebrate embryos

Annu Rev Cell Dev Biol. 2012;28:627-53. doi: 10.1146/annurev-cellbio-092910-154208. Epub 2012 Aug 16.

Abstract

Planar cell polarity (PCP), the orientation and alignment of cells within a sheet, is a ubiquitous cellular property that is commonly governed by the conserved set of proteins encoded by so-called PCP genes. The PCP proteins coordinate developmental signaling cues with individual cell behaviors in a wildly diverse array of tissues. Consequently, disruptions of PCP protein functions are linked to defects in axis elongation, inner ear patterning, neural tube closure, directed ciliary beating, and left/right patterning, to name only a few. This review attempts to synthesize what is known about PCP and the PCP proteins in vertebrate animals, with a particular focus on the mechanisms by which individual cells respond to PCP cues in order to execute specific cellular behaviors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cell Movement
  • Cell Polarity*
  • Cilia / metabolism
  • Cilia / physiology
  • Embryonic Development*
  • Facial Nerve / cytology
  • Facial Nerve / embryology
  • Facial Nerve / metabolism
  • Gene Expression Regulation, Developmental
  • Hair Cells, Auditory, Inner / metabolism
  • Hair Cells, Auditory, Inner / physiology
  • Hair Follicle / cytology
  • Humans
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology
  • Neural Tube / cytology
  • Neural Tube / metabolism
  • Neural Tube / physiology

Substances

  • Membrane Proteins