Effects of enhanced bolus flavors on oropharyngeal swallow in patients treated for head and neck cancer

Head Neck. 2013 Aug;35(8):1124-31. doi: 10.1002/hed.23086. Epub 2012 Aug 21.

Abstract

Background: Treatment for head and neck cancer can reduce peripheral sensory input and impair oropharyngeal swallow. This study examined the effect of enhanced bolus flavor on liquid swallows in these patients.

Methods: Fifty-one patients treated for head and neck cancer with chemoradiation or surgery and 64 healthy adult control subjects served as subjects. All were randomized to receive sour, sweet, or salty bolus flavor. Patients were evaluated at 7-10 days, 1 month, and 3 months after completion of tumor treatment. Control subjects received 1 assessment.

Results: All bolus flavors affected oropharyngeal swallow; sour flavor significantly shortened pharyngeal transit time across all evaluations.

Conclusions: Sour flavor influenced the swallow of patients treated for head and neck cancer, as well as that of control subjects in a manner similar to those with neurologic impairment observed in an earlier study. Sour flavor may improve the speed of pharyngeal transit regardless of whether a patient has suffered peripheral or central sensory damage.

Keywords: dysphagia; flavor; head and neck cancer; sensory; videofluorography.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Deglutition Disorders / physiopathology*
  • Deglutition Disorders / therapy*
  • Female
  • Flavoring Agents / therapeutic use*
  • Head and Neck Neoplasms / complications*
  • Head and Neck Neoplasms / physiopathology*
  • Head and Neck Neoplasms / therapy
  • Humans
  • Male
  • Middle Aged
  • Oropharynx / physiopathology
  • Taste*
  • Xerostomia / etiology
  • Xerostomia / physiopathology

Substances

  • Flavoring Agents