P2 receptors and immunity

doi:10.1016/j.micinf.2012.07.006

Review

. 2012 Nov;14(14):1254-62.

doi: 10.1016/j.micinf.2012.07.006. Epub 2012 Aug 13.

P2 receptors and immunity

Amel Rayah¹, Jean M Kanellopoulos, Francesco Di Virgilio

Affiliations

PMID: 22909902
PMCID: PMC3514633
DOI: 10.1016/j.micinf.2012.07.006

Review

P2 receptors and immunity

Amel Rayah et al. Microbes Infect. 2012 Nov.

. 2012 Nov;14(14):1254-62.

doi: 10.1016/j.micinf.2012.07.006. Epub 2012 Aug 13.

Authors

Amel Rayah¹, Jean M Kanellopoulos, Francesco Di Virgilio

Affiliation

¹ Institut de Biochimie et Biophysique Moléculaire et Cellulaire, CNRS UMR 8619, Université Paris Sud, 91405 Orsay Cedex, France.

PMID: 22909902
PMCID: PMC3514633
DOI: 10.1016/j.micinf.2012.07.006

Abstract

Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release, phagocytosis, Ag presentation and cytotoxicity. This makes P2 receptors an attractive target for the therapy of immuno-mediated disease and cancer.

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References

1. Burnstock G., Verkhratsky A. Evolutionary origins of the purinergic signalling system. Acta Physiol. 2009;195:415–447. - PubMed
1. Burnstock G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev. 2006;58:58–86. - PubMed
1. Lohmann K. Uber die pyrophosphatfraktion im muskel. Naturwissenschaften. 1929;17:624–625.
1. Drury A., Szent-Gyorgy A. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J. Physiol. 1929;68:213–237. - PMC - PubMed
1. Janeway C.A., Jr. How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. U.S.A. 2001;98:7461–7468. - PMC - PubMed

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[1] Burnstock G., Verkhratsky A. Evolutionary origins of the purinergic signalling system. Acta Physiol. 2009;195:415–447. - PubMed

[2] Burnstock G., Verkhratsky A. Evolutionary origins of the purinergic signalling system. Acta Physiol. 2009;195:415–447. - PubMed

[3] Burnstock G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev. 2006;58:58–86. - PubMed

[4] Burnstock G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev. 2006;58:58–86. - PubMed

[5] Lohmann K. Uber die pyrophosphatfraktion im muskel. Naturwissenschaften. 1929;17:624–625.

[6] Lohmann K. Uber die pyrophosphatfraktion im muskel. Naturwissenschaften. 1929;17:624–625.

[7] Drury A., Szent-Gyorgy A. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J. Physiol. 1929;68:213–237. - PMC - PubMed

[8] Drury A., Szent-Gyorgy A. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J. Physiol. 1929;68:213–237. - PMC - PubMed

[9] Janeway C.A., Jr. How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. U.S.A. 2001;98:7461–7468. - PMC - PubMed

[10] Janeway C.A., Jr. How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. U.S.A. 2001;98:7461–7468. - PMC - PubMed

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P2 receptors and immunity

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P2 receptors and immunity

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