C-type lectin receptors orchestrate antifungal immunity

Nat Immunol. 2012 Sep;13(9):817-22. doi: 10.1038/ni.2369. Epub 2012 Aug 21.


Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fungal Vaccines / immunology
  • Fungi / immunology*
  • Humans
  • Lectins, C-Type / immunology*
  • Mycoses / immunology
  • Receptors, Pattern Recognition / immunology
  • Signal Transduction / immunology*


  • Fungal Vaccines
  • Lectins, C-Type
  • Receptors, Pattern Recognition