Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array

Clin Pharmacol Ther. 2012 Oct;92(4):437-9. doi: 10.1038/clpt.2012.125. Epub 2012 Aug 22.


Although there is increasing evidence to support the implementation of pharmacogenetics in certain clinical scenarios, the adoption of this approach has been limited. The advent of preemptive and inexpensive testing of critical pharmacogenetic variants may overcome barriers to adoption. We describe the design of a customized array built for the personalized-medicine programs of the University of Florida and Stanford University. We selected key variants for the array using the clinical annotations of the Pharmacogenomics Knowledgebase (PharmGKB), and we included variants in drug metabolism and transporter genes along with other pharmacogenetically important variants.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cost-Benefit Analysis / economics
  • Cost-Benefit Analysis / methods
  • Cost-Benefit Analysis / trends
  • Genotype*
  • Humans
  • Oligonucleotide Array Sequence Analysis / economics*
  • Oligonucleotide Array Sequence Analysis / methods
  • Oligonucleotide Array Sequence Analysis / trends
  • Pharmacogenetics / economics*
  • Pharmacogenetics / methods
  • Pharmacogenetics / trends
  • Polymorphism, Single Nucleotide / genetics
  • Precision Medicine / economics*
  • Precision Medicine / methods
  • Precision Medicine / trends