Reduced T helper and B lymphocytes in Parkinson's disease

J Neuroimmunol. 2012 Nov 15;252(1-2):95-9. doi: 10.1016/j.jneuroim.2012.07.015. Epub 2012 Aug 19.


Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4+ T and CD19+ B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • B-Lymphocytes / immunology*
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Parkinson Disease / blood
  • Parkinson Disease / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology*