Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8

Jpn J Radiol. 2012 Nov;30(9):777-82. doi: 10.1007/s11604-012-0115-2. Epub 2012 Aug 23.

Abstract

We report a male case of beta-catenin-activated hepatocellular adenoma (HCA) focusing on findings of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI) and discussing the molecular background and possible clinical significance. The patient was a 31-year-old man in whom computed tomography (CT) showed a large nodule of 14 cm in diameter in the right liver lobe. On dynamic contrast-enhanced CT, heterogeneous and slight to moderate enhancement was observed during the early phase, with washout in the late phase. Focal fat deposits and a scar-like portion in the lesion were also seen. Most of the lesion was slightly hyperintense compared with the background liver on the hepatobiliary phase of EOB-MRI. After operation, this patient was confirmed pathologically as having beta-catenin-activated HCA with a portion suggestive of malignant transformation. In addition, intense organic anion transporter polypeptide 8 expression was observed throughout the tumor by immunohistochemical staining.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Liver Cell / chemistry*
  • Adenoma, Liver Cell / pathology*
  • Adult
  • Gadolinium DTPA
  • Humans
  • Immunohistochemistry
  • Liver Neoplasms / chemistry*
  • Liver Neoplasms / pathology*
  • Magnetic Resonance Imaging*
  • Male
  • Organic Anion Transporters, Sodium-Independent / analysis*
  • Solute Carrier Organic Anion Transporter Family Member 1B3
  • Tomography, X-Ray Computed
  • beta Catenin / physiology*

Substances

  • CTNNB1 protein, human
  • Organic Anion Transporters, Sodium-Independent
  • SLCO1B3 protein, human
  • Solute Carrier Organic Anion Transporter Family Member 1B3
  • beta Catenin
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA