New PET imaging agents in the management of solid cancers

Curr Opin Oncol. 2012 Nov;24(6):748-55. doi: 10.1097/CCO.0b013e32835766f7.


Purpose of review: (18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which has great importance in the era of individualized targeted therapies. PET-CT is an exquisite tool for molecular imaging because it allows detection of nanomolar quantities of tracer molecules targeting different hallmarks of cancer.

Recent findings: This article reviews the most recent findings (published in 2010-2011) on the use of molecular imaging for assessing tumour proliferation, apoptosis, growth receptor expression, bone metabolism, and hypoxia.

Summary: Molecular imaging using PET-CT constitutes a major opportunity in translational research bringing fundamental molecular insights to the clinical area. Such information results invaluable for patient selection and prediction of response to therapy and serves as a crucial diagnostic tool in the era of personalized medicine.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Cell Hypoxia
  • Cell Membrane / metabolism
  • Cell Proliferation
  • Choline / pharmacokinetics
  • Dideoxynucleosides* / pharmacokinetics
  • Heterocyclic Compounds, 1-Ring / pharmacokinetics
  • Humans
  • Multimodal Imaging*
  • Neoplasms / diagnostic imaging*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Peptides, Cyclic / pharmacokinetics
  • Positron-Emission Tomography*
  • Radiopharmaceuticals* / pharmacokinetics
  • Sodium Fluoride / pharmacokinetics
  • Somatostatin / analogs & derivatives
  • Somatostatin / pharmacokinetics
  • Tissue Distribution
  • Tomography, X-Ray Computed*


  • Dideoxynucleosides
  • Heterocyclic Compounds, 1-Ring
  • Peptides, Cyclic
  • Radiopharmaceuticals
  • gallium 68-DOTA-lanreotide
  • Somatostatin
  • Sodium Fluoride
  • Choline
  • alovudine