Atrial natriuretic peptide and adiponectin interactions in man

PLoS One. 2012;7(8):e43238. doi: 10.1371/journal.pone.0043238. Epub 2012 Aug 16.

Abstract

Reduced circulating natriuretic peptide concentrations are independently associated with insulin resistance and type 2 diabetes, while increased natriuretic peptide levels appear to be protective. Observations in vitro and in heart failure patients suggest that atrial natriuretic peptide (ANP) promotes adiponectin release, an adipokine with insulin sensitizing properties. We tested the hypothesis that ANP acutely raises adiponectin levels in 12 healthy men. We infused ANP intravenously over 135 minutes while collecting venous blood and adipose tissue microdialysates at baseline and at the end of ANP-infusion. We obtained blood samples at identical time-points without ANP infusion in 7 age and BMI matched men. With infusion, venous ANP concentrations increased ∼10 fold. Systemic and adipose tissue glycerol concentrations increased 70% and 80%, respectively (P<0.01). ANP infusion increased total adiponectin 14 ± 5% and high molecular-weight (HMW)-adiponectin 13 ± 5% (P<0.05). Adiponectin did not change in the control group (P<0.05 vs. infusion). ANP-induced changes in HMW adiponectin and adipose tissue lipolysis were directly correlated with each other, possibly suggesting a common mechanism. Our data show that ANP acutely increases systemic total and HMW-adiponectin concentrations in healthy subjects. Our study could have implications for the physiological regulation of adiponectin and for disease states associated with altered natriuretic peptide availability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / metabolism*
  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism
  • Adult
  • Atrial Natriuretic Factor / blood
  • Atrial Natriuretic Factor / metabolism*
  • Atrial Natriuretic Factor / pharmacology*
  • Glycerol / blood
  • Glycerol / metabolism
  • Humans
  • Male

Substances

  • Adiponectin
  • Atrial Natriuretic Factor
  • Glycerol

Grant support

Our work was supported in part by a grant from the Deutsche Forschungsgemeinschaft to ALB (Bl 1292/4-1), JJ (JO 284/5-2) and a collaborative research grant of the European Commission (SICA-HF, FP7 241558). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.