Hepatoprotective iridoid glycosides from the roots of Rehmannia glutinosa

J Nat Prod. 2012 Sep 28;75(9):1625-31. doi: 10.1021/np300509z. Epub 2012 Aug 23.

Abstract

Eleven new iridoid glycosides, rehmaglutosides A-K (1-11), together with 20 known analogues were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 3, 7, and 9-11 (10 μM) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Galactosamine / chemistry
  • Galactosamine / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Hepatocytes / drug effects*
  • Humans
  • Iridoid Glycosides / chemistry
  • Iridoid Glycosides / isolation & purification*
  • Iridoid Glycosides / pharmacology*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Rehmannia / chemistry*

Substances

  • Glycosides
  • Iridoid Glycosides
  • rehmaglutoside A
  • Galactosamine