neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production

Zhanping Sun; Yushan Li; Da-qing Jin; Ping Guo; Haibin Song; Jing Xu; Yuanqiang Guo; Lei Zhang

doi:10.1016/j.fitote.2012.08.003

neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production

Fitoterapia. 2012 Dec;83(8):1409-14. doi: 10.1016/j.fitote.2012.08.003. Epub 2012 Aug 21.

Authors

Zhanping Sun¹, Yushan Li, Da-qing Jin, Ping Guo, Haibin Song, Jing Xu, Yuanqiang Guo, Lei Zhang

Affiliation

¹ College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.

PMID: 22917649
DOI: 10.1016/j.fitote.2012.08.003

Abstract

A phytochemical investigation of the whole plants of Ajuga decumbens led to the isolation of three new (1, 2a, and 2b) and three known (3a-3c) neo-clerodane diterpenes. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HR-ESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of the six diterpenes were evaluated and compounds 2a, 2b, and 3a showed inhibitory effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ajuga / chemistry*
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line
Diterpenes, Clerodane / chemistry*
Diterpenes, Clerodane / classification*
Diterpenes, Clerodane / pharmacology
Lipopolysaccharides / toxicity*
Mice
Microglia / drug effects
Microglia / metabolism
Molecular Structure
Nitric Oxide / metabolism*

Substances

Antineoplastic Agents, Phytogenic
Diterpenes, Clerodane
Lipopolysaccharides
Nitric Oxide