neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production

Fitoterapia. 2012 Dec;83(8):1409-14. doi: 10.1016/j.fitote.2012.08.003. Epub 2012 Aug 21.


A phytochemical investigation of the whole plants of Ajuga decumbens led to the isolation of three new (1, 2a, and 2b) and three known (3a-3c) neo-clerodane diterpenes. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HR-ESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of the six diterpenes were evaluated and compounds 2a, 2b, and 3a showed inhibitory effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ajuga / chemistry*
  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line
  • Diterpenes, Clerodane / chemistry*
  • Diterpenes, Clerodane / classification*
  • Diterpenes, Clerodane / pharmacology
  • Lipopolysaccharides / toxicity*
  • Mice
  • Microglia / drug effects
  • Microglia / metabolism
  • Molecular Structure
  • Nitric Oxide / metabolism*


  • Antineoplastic Agents, Phytogenic
  • Diterpenes, Clerodane
  • Lipopolysaccharides
  • Nitric Oxide