Aiding and abetting roles of NOX oxidases in cellular transformation

Nat Rev Cancer. 2012 Sep;12(9):627-37. doi: 10.1038/nrc3339.


NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Cell Transformation, Neoplastic / metabolism*
  • Humans
  • NADPH Oxidases / metabolism*
  • Neoplasms / etiology*
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction / physiology


  • Reactive Oxygen Species
  • NADPH Oxidases