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Review
. 2012;62:59-69.
doi: 10.1007/978-94-007-4572-8_4.

Archaeal orc1/cdc6 Proteins

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Review

Archaeal orc1/cdc6 Proteins

Stephen D Bell. Subcell Biochem. .

Abstract

The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by archaeal initiators.

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