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. 2012;62:59-69.
doi: 10.1007/978-94-007-4572-8_4.

Archaeal orc1/cdc6 Proteins


Archaeal orc1/cdc6 Proteins

Stephen D Bell. Subcell Biochem. .


The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by archaeal initiators.

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